Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Results


PMID 26121987
Gene Name IGFBP3
Condition Endometriosis
Association Associated
Population size 925
Population details 925 (310 premenopausal women with incident endometriosis, 615 matched controls)
Sex Female
Associated genes IGF-1, IGFBP-3
Other associated phenotypes Endometriosis
A prospective study of insulin-like growth factor 1, its binding protein 3, and risk of endometriosis.

Am J Epidemiol. 2015 Jul 15;182(2):148-56. doi: 10.1093/aje/kwv037. Epub 2015 Jun

Mu, Fan| Hankinson, Susan E| Schernhammer, Eva| Pollak, Michael N| Missmer, Stacey A



Several retrospective case-control studies suggested that insulin-like growth factor 1 (IGF-1) or insulin-like growth factor binding protein 3 (IGFBP-3) was associated with endometriosis. However, results are inconsistent and no prospective study exists. We prospectively evaluated associations between plasma levels of IGF-1 and IGFBP-3 and laparoscopically confirmed endometriosis in a case-control study nested within the Nurses' Health Study II. Between blood collections in 1996-1999 and 2007, we ascertained 310 premenopausal women with incident endometriosis and 615 matched controls. We estimated incidence rate ratios and 95% confidence intervals using multivariable conditional logistic regression. We observed no statistically significant associations between endometriosis and IGF-1 (incidence rate ratio (IRR) = 0.88, 95% confidence interval (CI): 0.61, 1.27; Ptrend = 0.48), IGFBP-3 (IRR = 1.12, 95% CI: 0.80, 1.57; Ptrend = 0.51), and the IGF-1:IGFBP-3 molar ratio (IRR = 0.94, 95% CI: 0.66, 1.34; Ptrend = 0.64), comparing the top with the bottom tertile. IGF-1, IGFBP-3, and the molar ratio appeared to be positively associated with endometriosis risk among women aged <40 years at blood draw (IGF-1: IRR = 1.60, 95% CI: 0.86, 2.98; IGFBP-3: IRR = 1.85, 95% CI: 1.08, 3.16; IGF-1:IGFBP-3: IRR = 1.57, 95% CI: 0.85, 2.88) but not among women aged >/=40 years at blood draw (all Pheterogeneity
Mesh Terms: Adult| Biomarkers/blood| Case-Control Studies| Endometriosis/*blood| Female| Humans| Insulin-Like Growth Factor Binding Protein 3/*blood| Insulin-Like Growth Factor I/*metabolism| Prospective Studies| Risk Assessment|DA 2015/09/26 06:00